And until you've got a doctor-diagnosed deficiency in any of these nutrients that you can’t fill with food alone, there’s no actual must supplement at all. "At greatest, tremendous-excessive doses of nutrients are buying you costly urine, and at worst, they may contribute to the event of chronic diseases," she says. While studies show supplementing with high doses does help construct muscle mass and enhance strength over time, it’s not pre-workout within the strict sense, in that timing doesn’t actually matter. Taking smaller doses more regularly through the day could even be an possibility, however it's best to talk about any adjustments in your medicine timing or dosage along with your physician before experimenting by yourself. As an example, a 2017 study within the Journal of Clinical Oncology discovered that long-term supplementation with high doses of vitamin B6 and B12 may significantly increase the risk of lung most cancers in men